Bosi A, Xu Y, Gasparini A, et al. - Researchers sought to describe the use of nephrotoxic medications in patients with CKD Stage G3-5 in routine care.

• Researchers assessed cohorts of adults with confirmed CKD G3-5 undergoing routine care in the two health systems (Stockholm CREAtinine Measurements [SCREAM], Stockholm, Sweden [N = 57,880]; and Geisinger, Pennsylvania, US [N = 16,255]).

• Nephrotoxic medications were administered to one in five patients with CKD in the two distinct health systems.

• NSAIDs, antivirals and immunosuppressants were the top nephrotoxic medications identified in both cohorts.

• In both cohorts, risk of receiving nephrotoxic medications appeared to be higher for patients with age < 65 years, women, or with CKD G3.

• Prescription of nephrotoxic medications may reduce and iatrogenic kidney injury may be prevented with implementation of strategies to increase physician's awareness of patients’ CKD and knowledge of drug nephrotoxicity.