Su VYF, et al. - This investigation was carried out to assess the impacts of medication on acute exacerbation in patients with coexistent chronic obstructive pulmonary disease (COPD) and asthma. A lower risk of acute exacerbation was noted in association with LAMA (long-acting muscarinic antagonist) or ICS (inhaled corticosteroid)/LABA (long-acting beta 2 agonist) combinations use among patients with COPD and asthma.