Adelborg K, et al. - A nationwide population-based active-comparator study was conducted to investigate the relationship between histamine H₂ receptor antagonist (H₂RA) initiation and all-cause mortality among patients with heart failure. This cohort study consisted of new users of H₂RAs and proton pump inhibitors (PPIs) after first-time hospitalization for heart failure during the period 1995-2014. The results from the study indicate that H₂RA initiation was linked with 15%–20% lower mortality than PPI initiation in patients with heart failure.