Fehlmann T, Kahraman M, Ludwig N, et al. - This multicenter, cohort study intended to evaluate the use of blood-borne miRNAs as potential circulating markers for detecting lung cancer in an extended cohort of symptomatic patients and control participants. Between March 3, 2009, and March 19, 2018, this study involved individuals from case-control and cohort studies (TREND and COSYCONET) with 3,102 individuals being enrolled by convenience sampling. Population sampling was conducted for the cohort study TREND. They obtained clinical diagnoses for 3,046 individuals (606 patients with non–small cell and small cell lung cancer, 593 individuals with nontumor lung diseases, 883 individuals with diseases not affecting the lung, and 964 unaffected control participants). Researchers recruited a total of 3,102 individuals with a mean (SD) age of 61.1 (16.2) years. The data of this study implied that the distinguished patterns of miRNAs may be utilized as a component of a minimally invasive lung cancer test, complementing imaging, sputum cytology, and biopsy tests.