Halper A, et al. - By comparing 25 children with congenital adrenal hyperplasia (CAH) treated with anastrozole vs 31 children with CAH not treated with anastrozole, researchers assessed anastrozole’s effect in children with CAH with regard to bone mineral density (BMD) and visceral adipose tissue (VAT). Participants in the study had a pubertal exam, bone age X-ray, and dual X-ray absorptiometry (DXA) scan. In children with CAH and advanced bone age (>2SDs), anastrozole significantly decreased bone age advancement with no adverse effects on BMD or VAT. In order to validate these findings, longitudinal anastrozole studies in children with CAH are required.