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Use of a dual-antigen rapid diagnostic test to screen children for severe plasmodium falciparum malaria in a high-transmission, resource-limited setting

Clinical Infectious Diseases Aug 31, 2017

Boyce R, et al. – Authors conducted this prospective, observational cohort study to assess the accuracy of a dual–band (histidine–rich protein–2/pan–lactate dehydrogenase [HRP2/pLDH]) rapid diagnostic test (RDT) to differentiate uncomplicated from severe malaria. Findings suggested higher sensitivity of a positive dual–antigen (HRP2/pLDH) RDT in comparison to the use of clinical manifestations to detect severe malaria, making it a promising tool in the triage of children with malaria in low–resource settings. They recommend additional work to operationalize diagnostic and treatment algorithms that include dual–antigen RDTs to avoid over referral.
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