Vaisar T, et al. - Authors evaluated the relationship of urine complement proteins with progression to end-stage renal disease (ESRD) or death in people with type 2 diabetes and proteinuric diabetic kidney disease (DKD). Findings suggested a strong association of urine abundance of several complement and complement regulatory proteins with progression to ESRD and death in a largely Mexican-American cohort with type 2 diabetes and proteinuric DKD. Findings suggested an association of higher urine complement components 4 (C4) and C8 with lower risk of death. In fully adjusted models, an association between higher urine factor H–related protein 2, a positive regulator of the alternative complement pathway, and greater risk of death was noted.