Cui Y et al.

Summary - Based on the current study, the COX-2 pathway was shown to be involved in pancreatic carcinogenesis. Furthermore, the urinary prostaglandin E2 metabolite (PGE-M) may serve as a biomarker for predicting pancreatic cancer risk.

Methods
A case-control study was conducted with 722 subjects (239 cases and 483 controls) nested within two prospective cohort studies.
PGE-M was measured in urine samples using a liquid chromatography/tandem mass spectrometric method.

Results
Compared to subjects with the lowest level of urine PGE-M, subjects with higher urine levels of PGE-M had an increased risk of developing pancreatic cancer (aORs = 1.63, 1.55, and 1.94 for the 2nd-4th quartiles, respectively).