Patel AP, Mehta SS, White AJ, et al. - This study attempted to assess urinary hydroxylated polycyclic aromatic hydrocarbon metabolites (OH-PAHs) with all-cause and cause-specific mortality in a representative sample of the U.S. population. Cox proportional hazards regression was used to calculate adjusted hazard ratios and 95% confidence intervals for the association between ΣOH-PAHs and mortality endpoints. There were 934 all-cause deaths, 159 cancer-specific deaths, and 108 cardiovascular-specific deaths (median 6.75 years follow-up) in 9,739 eligible participants. They evaluated potential heterogeneity by age, gender, smoking status, poverty, and race/ethnicity. They analyzed the overall mixture effect using quantile g-computation. In the U.S. population. The outcomes support a role for total PAH exposure in all-cause and cause-specific mortality.