Goldstein SL, Krallman KA, Schmerge A, et al. - In this two-center prospective study, researchers ascertained if urine neutrophil gelatinase-associated lipocalin (uNGAL) is a reliable screening tool for acute kidney injury (AKI) in NINJA and may minimize the need for regular venipuncture. The sample consisted of 113 children who met NINJA criteria from May 2018 through March 2019. Daily urine samples were collected for up to the first 7 days of qualifying exposure and 2 days after exposure ended. To rule out severe AKI, urine NGAL thresholds of 150 and 300 ng/ml showed excellent specificity and negative predictive values. The authors propose that uNGAL may be used to replace some of the daily serum creatinine venipunctures in NINJA. Further study is required for the most optimal combination of serum creatinine and uNGAL assessment.