Hatton GE, Wang YW, Isbell KD, et al. - This prospective observational analysis was undertaken to determine whether acute kidney injury (AKI) development in severely injured trauma patients can be accurately predicted by urinary tissue inhibitor of metalloprotease 2 (TIMP-2) × insulin-like growth factor binding protein 7 (IGFBP-7). Participants were adult (≥16 years old) trauma ICU patients (n = 88). Experts employed the optimal threshold generated by a Youden index in order to conduct univariate, multivariable, and receiver operating characteristic curve analyses. A TIMP-2 × IGFBP-7 of 0.17 U was identified in patients without early AKI, while a TIMP-2 × IGFBP-7 of 0.46 U was detected in those with early AKI. Findings revealed that not only accurate prediction of 48-hour AKI was enabled by urinary TIMP-2 × IGFBP-7 measured on ICU admission, but also it was shown to be independently related to AKI and dialysis need post-trauma and was concluded to be a promising screening instrument for treatment.

urinary TIMP-2 × IGFBP-7 measured on ICU admission accurately predicted 48-hour AKI and was independently associated with AKI and dialysis requirement after trauma and is a promising screening tool for treatment.