Urinary biomarkers profiles in patients with neurogenic detrusor overactivity according to their neurological condition
World Journal of Urology Nov 21, 2019
Richard C, Bendavid C, Hascoet J, et al. - A prospective single-center study was carried out between March 2015 and March 2017 on individuals aged over 18 years old, with neurological disease, with a urodynamic diagnosis of neurogenic detrusor overactivity (NDO) in order to examine the disease-specific urinary levels differences of neurotrophins (NGF, BDNF), mediators of inflammation (TGFβ-1, PGE-2) and markers of extracellular matrix alterations in individuals with multiple sclerosis (MS) spinal cord injury (SCI), or spina bifida, and NDO. Forty-one individuals were involved, ie, six with MS, 20 with SCI, and 15 with spina bifida. It was observed that all NDO may not be made even from a molecular standpoint. Compared with those in other neurologic populations with NDO, greater urinary levels of neurotrophins were noted in MS individuals. In comparison with SCI persons, urinary TGFβ-1, a robust determinant of the extracellular matrix, was notably greater in spina bifida individuals. Thus, these findings emphasize the significance of using and explaining those potential urinary markers in a disease-specific fashion.
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