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Urinary biomarkers for early detection of platinum based drugs induced nephrotoxicity

BMC Nephrology Sep 08, 2018

Abdelsalam M, et al. - Researchers assessed urinary biomarkers (KIM-1, NGAL and cystatin C) for their utility for early detection of acute kidney injuries (AKI) in patients receiving platinum based drugs (PBD) in a prospective cohort design. Participants in the study were 132 patients receiving PBD. These findings suggested that urinary KIM-1, Cystatin C and NGAL can forecast PBD induced AKI in earlier stages than serum creatinine. In patients receiving PBD, KIM-1 is the most sensitive biomarker for early detection of AKI.

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