Ren W, Huang Q, Fan K, et al. - Since gender differences in serum uric acid (SUA) levels and the risk of isolated distal deep vein thrombosis (IDDVT) have been discovered, researchers sought to investigate the relationship between gender, SUA, and IDDVT in stroke patients. Participants in the study were 3,404 patients and were divided into two groups: IDDVT (n = 1,233) and Non-IDDVT (n = 2,171) groups. SUA was found to be protective against IDDVT in stroke patients. Females were at a higher risk of IDDVT, which could be attributed to lower SUA levels than males. More emphasis should be placed in clinical practice on the risk of IDDVT in females, particularly those with lower SUA levels.