Fahmy O, et al. - Researchers carried out an appraisal of the incidence and risk factors of urethral recurrence (UR) post-radical cystectomy (RC) and its effect on survival. No prominent effect was yielded by the muscle invasion, carcinoma in situ and prostatic stromal or urethral involvement at time of RC on UR. Orthotopic neobladder exhibited a connection with a substantial, lower risk of UR after RC.

Methods

• Based on the PRISMA statement, a systematic online search was carried out for publications reporting on UR after RC.
• A total of 14 articles from initial 802 results, were included finally.
• It included 6,169 patients.

Results

• As per findings, the incidence rate of UR was discovered to be 4.4% (1.3%-13.7%).
• It appeared to be substantially lower with neobladder diversion (odds ratio = 0.44, 95% CI: 0.24-0.79, P=0.006).
• Muscle invasion (hazard ratio = 1.18, 95% CI: 0.86-1.62, P=0.31), carcinoma in situ (hazard ratio 0.97, 95% CI: 0.64-1.47, P= 0.88), prostatic stromal involvement (hazard ratio = 2.26, 95% CI: 0.01-627.75, P=0.78), and prostatic urethral involvement (hazard ratio = 2.04, 95% CI: 0.20-20.80, P=0.55) did not exert any major impact on UR.
• Men exhibited a susceptibility toward higher incidence of UR (odds ratio = 2.21, 95% CI: 0.96-5.06, P= 0.06).
• It was noted that the absence of recurrence illustrated a tendency toward better disease specific survival.
• However it was not significant (hazard ratio = 0.84, 95% CI: 0.66-1.08, P=0.17).
• The results displayed limitation owing to the retrospective nature of the included studies.