Zhang H, Geng Y, Sun C, et al. - Researchers intended to clarify the impact of epithelial cell transforming sequence 2 (ECT2) on 5-fluorouracil (5-Fu) resistance in gastric cancer (GC). They used RT-qPCR and Western blot analysis to determine gene expression. They found stomach adenocarcinoma and GC tissues exhibited upregulation of ECT2. As a consequence of ECT2 knockdown, the resistance of 5-FU in GC cells was weakened. A decrease in the cell migratory and invasive abilities of GC cells treated with 5-FU was caused by ECT2 silencing. Findings demonstrated ECT2 upregulation can not only predict adverse clinical results but also increase 5-FU resistance in GC patients.