Upregulated bone morphogenetic protein 5 enhances proliferation and epithelial–mesenchymal transition process in benign prostatic hyperplasia via BMP/Smad signaling pathway
The Prostate Sep 29, 2021
Liu D, Liu J, Li Y, et al. - According to novel findings in this study, cell proliferation and the epithelial–mesenchymal transition (EMT) process in benign prostatic hyperplasia (BPH) are modulated by bone morphogenetic protein 5 (BMP5) via the BMP/Smad signaling pathway which could contribute to the development of BPH. BMP/Smad signaling may be re-identified as a promising new treatment target for BPH management.
According to recent studies, BMP5 is upregulated in BPH tissues.
Human prostate cell lines (BPH-1, WPMY-1) and human/rat hyperplastic prostate tissues were used.
Upregulation of BMP5 was found in human and rat hyperplastic tissues, and BMP5 was localized both in the epithelial and stromal compartments of the prostate tissues.
Cell proliferation and the EMT process were enhanced by BMP5 overexpression through phosphorylation of Smad1/5/8, while BMP5 knockdown caused cell cycle arrest at G0/G1 phase and blocked the EMT process.
The impacts of BMP5 silencing and overexpression were reversed by a BMP/Smad signaling pathway agonist and antagonist, respectively.
In addition, a positive correlation of BMP5 expression with prostate volume as well as with total prostate-specific antigen was evident.
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