Cheng SH, et al. - In patients with unresectable pancreatic ductal adenocarcinoma (PDAC), including both unresectable locally advanced and metastatic PDAC, who were treated with chemotherapy, researchers ascertained whether computed tomographic (CT) texture analysis measurements of the tumor were independently correlated with progression-free survival (PFS) and overall survival (OS). Findings revealed that medium SD of more than 38.38 and coarse SD of more than 40.67 were linked to longer PFS after chemotherapy. A significant positive prognostic factor for OS was higher medium SD of 38.38 or greater. In patients with unresectable PDAC treated with chemotherapy, pretreatment CT quantitative imaging biomarkers from texture analysis are associated with PFS and OS, and the combination of pretreatment texture parameters and tumor size has the potential to perform better in survival models than biomarker imaging alone.