Tanimura K, et al. - This prospective cohort study was planned to examine the efficacy of maternal screening for congenital cytomegalovirus infection (CCI) using cytomegalovirus (CMV) immunoglobulin G (IgG) and the IgG avidity index (AI). Researchers identified the potential of maternal screening using CMV IgG and AI in identifying pregnancies with CCI from primary infection, however, the screening overlooked a number of those from nonprimary infection.