Singh SR, et al. - Considering that age-related macular degeneration (AMD) is a leading cause of blindness worldwide characterized by presence of drusen, leading to retinal pigment epithelium (RPE) and outer retinal changes in advanced stages, researchers sought to address unique optical coherence tomography (OCT)-based signs, their pathogenesis, clinical relevance, and management. Findings revealed that nearly 10% of eyes with AMD develop neovascular complications and present with subretinal or sub-RPE exudation, hemorrhage, or both. Although uncommon, multiple signs based on OCT are reported which can be difficult to clinically appreciate. Prompt identification of such signs as outer retinal tubulation, cystoid degeneration or pseudocysts can prevent unnecessary interventions. In addition, certain OCT-based features involving the choroid, like prechoridal cleft, choroidal cavern, have also been observed in AMD eyes.