Fang H, et al. – An analysis was performed to examine if an undetectable tissue transglutaminase (tTG) immunoglobulin A (IgA)<1.2 U/mL was more predictive of healing compared to patients with negative but detectable serology (1.2–3.9 U/mL). An undetectable titre was correlated with normal histology on follow–up biopsy in subjects recovering from coeliac disease with negative tTG IgA serology.

• Between January 2009 and December 2015, the authors conducted a retrospective study of 402 treated coeliac disease patients seen at the Mayo Clinic with negative tTG IgA values drawn within 1 month of duodenal biopsy.
• They used the Corazza-Villanacci score to evaluate mucosal healing.
• They also collected the presence of gastrointestinal symptoms.
• They used logistic regression to evaluate the relationship of clinical variables with a normal biopsy.

• Compared to patients with detectable tTG IgA levels, patients with undetectable titres more frequently had normal duodenal histology (117/240 vs. 53/162; OR=1.96; 1.292, 2.961).
• As compared to symptomatic patients, asymptomatic patients more frequently had normal duodenum (88/163 vs. 82/239; OR=2.25; CI: 1.494, 3.377).
• Compared to patients with detectable serology, patients with undetectable serology and on a gluten-free diet for ≥2 years were more likely to have no villous atrophy (148/192 vs. 55/88; OR=2.02; CI: 1.17, 3.49).