Price-Feeney M, et al. - Researchers examined responses from a national quantitative cross-sectional survey of more than 25,000 lesbian, gay, bisexual, transgender, queer, and questioning youth, aged between 13 and 24 years, in the US to better understand the mental health of transgender and nonbinary youth. Compared with cisgender lesbian, gay, bisexual, queer, and questioning youth, transgender and nonbinary youth were at increased risk of experiencing depressed mood, seriously considering suicide, and attempting suicide. Within-group analyses highlighted especially heightened risk for negative mental health outcomes among transgender males and nonbinary youth assigned male at birth. Findings point to the need to tackle transgender and nonbinary youth's needs specifically in prevention and intervention programs, and to promote policies that eliminate discrimination and victimization based on sexual orientation or gender identity.