Zhu L, Zhang J, Wang J, et al. - This study was undertaken to explore the mechanism underlying systemic lupus erythematosus (SLE)-related bone loss by assessing the bone mineral density (BMD) and bone turnover markers (BTMs) in premenopausal patients with new-onset SLE without any treatment. Researchers examined bone mineral density (BMD) and BTMs of 106 premenopausal patients with new-onset SLE and 64 genders-, age- and body mass index (BMI)-matched healthy controls. Dual-energy x-ray absorptiometry (DXA) was used to ascertain BMD. They further assessed serum BTMs. The results of this study demonstrate that premenopausal individuals with new-onset SLE had decreased BMD and abnormal bone metabolism with increased β-CTX and decreased OC and P1NP levels, demonstrating uncoupled bone remodeling in new-onset SLE patients. It has been reported that the disease activity and abnormal immunity, particularly the number of antibodies in SLE patients, were strongly correlated with the abnormality of bone metabolism.