Sethi A, Kodumuri V, Prasad V, et al. - Researchers here compared performance of the latest ultrathin strut biodegradable polymer sirolimus-eluting stents (BP-SES) to durable polymer everolimus-eluting stent (DP-EES), by analyzing relevant randomized controlled trials identified from electronic databases. In terms of stent thrombosis, target lesion revascularization, target vessel myocardial infarction, cardiac death and target vessel failure, there was no difference between the stents. No difference was observed in target lesion failure (TLF). BP-SES was associated with reduced TLF in small vessels, as evident based on the definition used. Findings revealed a comparable performance of the latest generation BP-SES vs DP-EES but the former failed to demonstrate superiority. The likely advantage in cases with small vessels should be explored in future trials.