Minami Y, et al. - For this research, the physicians evaluated the clinical feasibility of ultrasound-ultrasound (US-US) image overlay fusion with evaluation of the ablative margin in radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). US-US image overlay fusion could be proposed as a feasible guidance in RFA with a safety margin. This technique predicted the early response of treatment assessment with high accuracy.