Khera T, Murugappan KR, Leibowitz A, et al. - Researchers investigated how pecto-intercostal fascial plane block (PIFB) affects postoperative opioid requirements, pain scores, lengths of intensive care unit and hospital stays and incidence of postoperative delirium in cardiac surgical patients via performing a single- center, prospective, randomized (1:1), quadruple- blinded, placebo-controlled trial. They randomly assigned 80 adult cardiac surgical patients (age > 18 y) requiring median sternotomy to receive ultrasound-guided PIFB, with either 0.25% bupivacaine or placebo, on postoperative days 0 and 1. Outcomes suggested a decline in cumulative opioid consumption postoperatively in correlation with receiving PIFB with bupivacaine, but this difference between the groups was not statistically significant. They suggest that PIFB can be performed safely in this population as there were low incidence of complications and improvement in visual analog scale pain scores.