Chen H, Song H, Wang W, et al. - Via performing a randomized, double-blind, placebo-controlled trial, researchers sought to examine the effectiveness of ultrasound-guided parasternal intercostal nerve block for postoperative analgesia in patients undergoing median sternotomy for mediastinal mass resection. The trial was performed enrolling 41 patients who were scheduled for mediastinal mass resection by median sternotomy. Participants were randomized to receive 2 injections of ropivacaine (PSI) or saline (control) preoperatively, in the 3rd and 5th parasternal intercostal spaces with ultrasound-guided (USG) bilateral parasternal intercostal nerve block. All participants were administered sufentanil via patient-controlled intravenous analgesia (PCIA) postoperatively. Outcomes revealed USG bilateral parasternal intercostal nerve block as effective in reducing postoperative pain and adjuvant analgesic requirement, with good patient satisfaction. Hence, it constitutes a good option for mediastinal mass resection by median sternotomy.