Drost L, Hynynen K, Huang Y, et al. - A pilot study was carried out to explore a stand-alone, portable FUS device guided by diagnostic ultrasound alone (ultrasound [US]-guided FUS). Nine individuals were treated; safety and efficacy were evaluated for 10 d after the procedure, and medical charts were estimated to measure durability of pain response. With four individuals reporting minor skin-related irritations, the procedure was safe and tolerable. After the follow-up period, six individuals had durable pain relief. This research gives the indication that US-guided FUS is a reliable, tolerable and versatile procedure. It seems to be effective in achieving durable pain responses in individuals with painful bone metastases. An additional study is needed to improve technology and optimize its efficacy.