Caimmi C, De Marchi S, Bosello SL, et al. - Data on macrovascular involvement in systemic sclerosis (SSc) are still debatable. This study was intended to calculate its prevalence and possible determinants in a large cohort. Researchers recruited a total of 155 outpatients with SSc [Mean age was 57.9 ± 14.5 years and most were female (88.4%) with a limited subset (63.2%)]. They obtained data about disease characteristics and cardiovascular risk factors and patients underwent ecocolor Doppler ultrasonography of arteries of the neck and lower and upper limbs. The data revealed that macrovascular involvement was found to be quite common in SSc and that some disease characteristics linked to microvascular involvement are correlated with atherosclerotic plaques, which can be present even in early disease. This research imply that a complete assessment of macrocirculation is mandatory for rheumatologists treating SSc patients.