De Milliano I, Middelkoop MA, Huirne JAF, et al. - In this study, researchers sought to report on the effect of ulipristal acetate (UPA) vs gonadotropin-releasing hormone agonists (GnRHa) before laparoscopic myomectomy on long term secondary outcomes of the MYOMEX-trial, which comprise quality of life, ultrasound characteristics, hemoglobin levels 6 weeks post-operative, sexual function and menstrual bleeding control. Further, they performed a cost-analysis. A double-blind, randomized, controlled, non-inferiority trial was performed in nine hospitals in the Netherlands including a total of 55 participants; 30 of these participants were randomized to the UPA- and 25 to the GnRHa-group between May 2015 and July 2017. Per outcomes, administration of UPA vs GnRHa prior to laparoscopic myomectomy had similar effects on bleeding pattern, menopausal symptoms, sexual functioning, symptom severity and quality of life from baseline up to 6 months postoperative. Due to the small sample size, researchers emphasize cautiously interpreting these findings. Further, no firm conclusions could be made on costs.