Luo P, et al. - Study authors carried out this investigation to explore how hepatic steatosis, insulin resistance, and inflammation are influenced by ubiquitin-specific peptidase 10 (USP10), a member of the ubiquitin-specific protease family. In the fatty livers of patients with nonalcoholic fatty liver disease, obese mice and palmitate-treated hepatocytes, USP10 expression was significantly decreased. It was noted that USP10 inhibits hepatic steatosis, insulin resistance, and inflammation via Sirt6. In response to high-fat diet (HFD) treatment, Sirt6 deficiency decreased the ameliorative effects of USP10 overexpression.