U-shaped association of plasma testosterone, and no association of plasma estradiol, with incidence of fractures in men
Journal of Clinical Endocrinology and Metabolism Mar 18, 2020
Yeap BB, Alfonso H, Chubb SAP, et al. - Researchers intended to determine if there is an associations between different sex hormones and incidence of any bone fracture or hip fracture in older men. The sample consisted of 3,307 community-dwelling men (aged 76.8 ± 3.5 years) median follow-up period of 10.6 years. According to results, incident fractures occurred in 330 men, including 144 fractures of the hip. Mid-range plasma T was linked to lower incidence of any fracture and hip fracture, and higher sex hormone-binding globulin with increased risk of hip fracture. Circulating androgen rather than estrogen is a biomarker of hormonal effects on bone fracture risk.
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