Tyrosine kinase inhibitor, vatalanib, inhibits proliferation and migration of human pterygial fibroblasts
Cornea Aug 14, 2017
Kim HK, et al. – The impacts of vatalanib on the proliferation and migration of cultured human pterygial fibroblasts (HPFs) are examined in this study. These outcomes demonstrate that vatalanib significantly suppressed the proliferation and migration of HPFs by reducing vascular endothelial growth factor and transforming growth factor–β. Vatalanib exhibited less toxicity than that of Mitomycin C (MMC). Based on these results, vatalanib may potentially serve as a new adjuvant treatment after pterygium excision surgery.
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