Nabatanzi A, et al. - Researchers describe a rare case of acquired cutis laxa in a 45-year-old Chinese lady who developed this disease condition following a recurrent urticaria-like eruption in the absence of an autoimmune disease, neoplasm, drugs and or syndrome. She stated a 1-year history of widespread pruritic urticarial eruption and a 6-month history of progressive skin wrinkling. There was no family history of similar conditions. Hypersensitivity and atrophy were evident on biopsy. Antihistamines were used for treatment, following the Food and Drug Administration guidelines, resulting in relief in itching but her hyperpigmentation and cutis laxa never improved. The possible link between a decrease of elastic fibers and the infiltration of inflammatory cells in the dermis was suggested. This implies a possible major role of chemical mediators in the destruction of elastic fibers, therefore leading to cutis laxa development. In order to decide if the condition is inherited or acquired, taking a full clinical and family history was recommended to practitioners.