Semprini R, et al. - The link between Type 2 biomarkers, blood eosinophils, FeNO (fraction exhaled nitric oxide), serum periostin, serum IgE (immunoglobulin E) and time to severe exacerbation was studied in a broad asthma population, using multivariate models. A total of 212 participants were followed for a median (range) 3.8 (1.1 to 5.3) years. In populations with severe refractory asthma, a positive link was noted between Type 2 biomarkers and risk of severe exacerbations. This did not extend to mild and moderate asthma. In a broad asthma population, non-Type 2 asthma could be a phenotype associated with an increased risk of severe exacerbations.