Semova I, Levenson AE, Krawczyk J, et al. - Since the knowledge on the changes in cholesterol metabolism in type 1 diabetes is essential to optimize therapy and prevent cardiovascular disease in people with type 1 diabetes, therefore, researchers compared youth with and without type 1 diabetes with respect to plasma levels of campesterol and β-sitosterol, markers of cholesterol absorption, as well as lathosterol, a marker of cholesterol synthesis. There were 175 adolescents with type 1 diabetes with a mean age 15.2 years and mean duration of diabetes 8.2 years. Those without diabetes were 74 in total, with a mean age 15.4 years. Participants with type 1 diabetes had 30% higher campesterol and β-sitosterol levels. A positive correlation of campesterol and β-sitosterol levels with hemoglobin A1c levels was also observed. Findings revealed 20% lower levels of lathosterol in participants with type 1 diabetes, as well as positive correlation of lathosterol levels with triglycerides, body mass index, and systolic blood pressure. A rise in cholesterol absorption, whereas a reduction in cholesterol synthesis in type 1 diabetes was suggested by the analysis of plasma markers.