Gjika E, et al. - For adult native joint bacterial arthritis, researchers sought the optimal length of postsurgical antibiotic therapy in this prospective, unblinded, randomized, non-inferiority study. They assessed 2 vs 4 weeks of antibiotic therapy following surgical drainage of native joint bacterial arthritis in adults. One hundred fifty-four cases (77 in the 4-week arm and 77 in the 2-week arm) were enrolled. With regard to cure rate, adverse events or sequelae outcomes revealed noninferiority of 2 weeks of targeted antibiotic therapy vs 4 weeks after initial surgical lavage for septic arthritis. At least for hand and wrist arthritis, it leads to a significantly shorter hospital stay.