Hofvind S, et al. - First-generation digital breast tomo-synthesis, including two-dimensional (2D) synthetic mammograms, was compared to digital mammography in a population-based screening program. BreastScreen Norway offers two-view (craniocaudal and mediolateral oblique) mammographic screening to all women aged 50-69 years every 2 years with independent double reading with consensus. For this randomized, controlled trial with a parallel group design, all 32 976 women who attended the program in Bergen in 2016-2017 were asked to participate. As a screening tool for detecting breast cancer, no significant difference was evident between digital breast tomosynthesis including synthetic 2D mammograms vs standard digital mammography. Researchers suggest the necessity for better understanding regarding the impact of digital breast tomosynthesis in population-based breast cancer screening by performing economic analyses and follow-up studies on interval and consecutive round screen-detected breast cancers.