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Two different composite markers predict severity and threshold dose in peanut allergy

The Journal of Allergy and Clinical Immunology: In Practice Nov 07, 2020

Cottel N, Saf S, Heck MB, et al. - This study was sought to evaluate biological markers correlated with the severity and threshold dose of an allergic reaction during an oral food challenge (OFC) in a population of children with peanut allergy (PA). Researchers obtained demographic and biological parameters of children with peanut OFC and basophil activation test (BAT) results. Individuals were classified into 2 severity groups (mild-to-moderate and severe) and 2 cumulative threshold dose groups: low ≤ 100 mg crushed peanut and high >100 mg. A total of 68 children were included in the study. The data exhibited that in children with PA, distinct composite markers including BAT allergen-specific and non–allergen-specific parameters appear to be correlated with severity and cumulative threshold dose.

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