Simsek IE, et al. - Among patients with a history of nonsteroidal anti-inflammatory drug hypersensitivity (NSAID-H), researchers assessed the impact of the drugs [acetyl salicylic acid (ASA) or culprit NSAID)] used in the initial oral provocation test (OPT) on the total number of OPTs needed to confirm NSAID-H. Using medical records, information was extracted on the demographic and clinical characteristics, coexisting chronic or allergic disease, and laboratory results. They also reviewed the drug employed for the initial OPT (ASA or culprit NSAID), results of the OPT, and the total number of OPTs. Overall 56 children with suspected hypersensitivity reaction to NSAIDs were analyzed, including 21 children (37.5%) with NSAID-H confirmed. Findings revealed that NSAID-H can be diagnosed with much lower numbers of OPT and patient compliance can be improved by performing an initial OPT with ASA, irrespective of patients' reaction history.