Schroeder M, et al. - Using the SMR, researchers sought to determine the risk factors for visual acuity (VA) below ≤ 35 letters of the Early Treatment Diabetic Retinopathy Study due to nAMD during a two-year follow-up. Evaluation of 6,142 treatment-naïve eyes was done, with a focus on a subgroup of 780 eyes with final VA outcome of ≤ 35 letters, concerning variations of baseline characteristics, change of VA, number of injections and choice of drug to predict the visual outcome. A decline to a final VA of ≤ 35 letters was reported in 12.7% of eyes that were treated for wet AMD and studied for 2 years. Visual decline to ≤ 35 letters during the two-year follow-up seemed to be significantly influenced by following baseline characteristics: visual acuity, worse-seeing eye treated, age and membrane size.