Kochi M, et al. - Researchers explored whether morphological-measured stromal and intra-tumour tumour-infiltrating lymphocytes (TILs) levels were associated with gene expression profiles. Also, they investigated whether TILs-associated genomic signature (GS) could be used to predict clinical outcomes and response to therapies in several breast cancer subtypes. As evaluated using hematoxylin eosin (HE), an association was reported between TILs-GS and stromal as well as intra-tumour TILs levels. It predicted prognosis and chemotherapy response in several breast cancer subtypes.