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Tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation

Modern Pathology Feb 19, 2020

Williams DS, Mouradov D, Newman MR, et al. - Researchers intended to describe whether tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation. This study included a total of 1,643 individuals with stage II/III cancer for tumour mucinous component, DNA mismatch repair (MMR) status, BRAF mutation and tumour infiltrating lymphocytes (TILs). The study found that mucinous component and mucinous stage II/III CRCs show clinico-molecular resemblances, with histological grade and BRAF mutation lacking prognostic value. It was indicated that prognosis for these tumours was instead strongly correlated with TIL status, with the most favourable results in TIL-high dMMR tumours, whilst TIL-low tumours had poor results irrespective of MMR status.
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