Xie K, et al. – This meta-analysis was planned to determine the relationship between tumor volume and prognosis of head and neck cancer (HNC). For assessing local control, overall survival (OS) and disease free survival (DFS) of patients with HNC, the gross tumor volume (GTVp) and metabolic tumor volume (MTVp) were highly significant. In addition, these markers could be used as the adjuvant and complementary index for a new T staging system in HNC.