Malakorn S, Ouchi A, Hu CY, et al. - Given that right-sided primary tumor location is correlated with worse prognosis in metastatic colon cancer, however, the effect of sidedness on recurrence, and prognosis for non-metastatic disease is less well known, researchers sought to explore the connection between sidedness, recurrence, and survival among patients with localized colon cancer. Consecutive patients who underwent curative colon cancer resection (2006-2013) were identified from a prospective database and retrospectively analyzed. Six hundred seventy-three patients (347 right-sided) were evaluated in this analysis. According to findings, tumor sidedness was not associated with recurrence risk in patients with colon cancer who have undergone curative resection. However, right-sidedness was correlated with unique recurrence patterns and inferior survival after recurrence among patients who developed recurrence. Treatment stratification should not be based on tumor sidedness alone for patients presenting with localized disease.