Salah S, et al. - Researchers sought to determine the prognostic role of tumor necrosis following neoadjuvant therapy in soft tissue sarcomas (STS). For this purpose, they analyzed data from studies that investigated neoadjuvant therapy in STS, focusing on survival based on the extent of necrosis, or those studies that provided individual patient data allowing estimation thereof. They found that in patients with STS, tumour necrosis < 90% following neoadjuvant therapy was associated with increased recurrence risk and inferior overall survival. They also observed that there was no link between poor necrosis and age, gender, or histologic soft tissue sarcoma subtypes. However, isolated limb perfusion was found to be related to higher odds of achieving ≥90% necrosis.