Neal MEH, Smith JD, Birkeland AC, et al. - Researchers conducted this retrospective study to assess the role of pretreatment tumor-infiltrating lymphocytes (TILs) in patients with advanced larynx squamous cell carcinoma (LSCC) undergoing the bioselection paradigm. Patients with advanced LSCC treated with bioselection and available tissue were involved (N = 76). The median TIL count was used to divide patients into CD8-low and CD8-high cohorts. A high CD8 TIL count was an independent predictor of improved 5-year disease-specific survival after controlling for tobacco use, tumor site, and stage. Such findings support previous information published by the group showing that TILs are predictive of disease-specific survival in patients with head and neck cancer. CD8 TIL counts were found to be significantly related to the degree of clinical response following induction chemotherapy. These findings imply that assessing tumor-infiltrating CD8 cells prior to treatment could be useful in patient selection.