Yang L, Pang C, Xu F, et al. - Since recurrence or metastasis is the cause for death in nearly 30% of stage IA non-small-cell lung cancer patients, researchers undertook this retrospective and two-center study to predict recurrence or metastasis in high-risk stage IA lung adenocarcinoma (LADC) patients who received radical resection. with the intention of predicting disease-free survival, a nomogram was developed based on multivariate analysis. This analysis involved 1,584 patients with pathological stage IA LADC who were treated with radical surgery. A nomogram incorporating tumor differentiation and EGFR mutation was found to have a higher C-index of 0.880 vs 0.598 for the AJCC 8th TNM staging system. Overall, a novel nomogram including tumor differentiation and EGFR mutation was developed to predict recurrence or metastatic likelihood in stage IA LADC patients who received radical surgery. With the help of this nomogram, not only patients in the high-risk group could be detected but also guidance for adjuvant treatment in the future could be gained. The 3-year cumulative nonrecurrence rate, when stratified by this model, was 21.8% in the high-risk group vs 98.1% in the low-risk group.