Petrova E, Zielinski V, Bolm L, et al. - In total, 119 individuals resected for pancreatic ductal carcinoma from 1996 to 2015 were involved in this retrospective study in order to examine the relationship between tumor budding and perineural invasion and their prognostic role in pancreatic ductal adenocarcinoma. In the univariable Cox regression, despite the quantification strategy, high tumor budding was an important negative prognostic factor. In the multivariable model adjusting for stage and standard histopathological parameters, independent negative prognostic factors were lymph vessel invasion and tumor budding > 5 buds/0.237 mm², whilst a positive prognostic factor was an adjuvant therapy. For the perineural invasion, no important prognostic value could be described. In summary, in pancreatic ductal adenocarcinoma related to lymph node metastasis, tumor budding is an independent negative prognostic factor. However, the prognostic role of perineural invasion continues to be unclear.