Ojalvo LS, et al. - Experts undertook this study in order to examine the tumor microenvironment (TME) of primary and recurrent epithelial ovarian cancer (EOC). It was reported that the tumor-associated macrophage (TAM) density did not exert an impact on the patient survival. Yet, longer overall survival (OS) from recurrence was revealed in patients with increased TAMs at recurrence (n=5) compared to patients without increased TAMs (n=12) (56.0 vs 20.0 months). It was also deduced that with the small sample size, this did not reach statistical significance. A necessity arose for further characterization of the evolution of the TME.